Department News
Cardiovascular Disease and Hemorheology
Seminar Date
2003-09-09
Author
박경시
Date
2003-09-09
Views
1729
1. 제 목 : Cardiovascular Disease and Hemorheology
2. 연 사 : Young I. Cho Professor
( Mechanical Engineering Department, Drexel University, Philadelphia, U.S.A.)
3. 일 시 : 2003년 9월 16일 (화) 16:00-17:00
4. 장 소 : 301동 1512호 (세미나실)
5. 내 용 :
Historically, atherosclerosis research has focused on the histology of the vascular wall and the biochemistry of clotting factors, platelets, prostaglandins and other biochemical factors. Although this “biochemical” approach to the study of atherogenesis has provided valuable information regarding the role played by histological and biochemical factors in the development of atherosclerosis, it has not identified the initiating event in atherosclerosis. The fundamental shortcoming of current biochemical theories is that they do not identify the initiating event that precedes endothelial injury.
We propose a protective adaptation theory, where a mechanical injury is the initiator of the endothelial injury. Damaged intima, lesions, and occlusions in the vascular system are secondary responses to mechanical injury that is directly related to the work of the heart. The arterial system is a dynamic system that naturally responds in various ways to different types of blood flow. In our approach, certain types of blood flow may cause mechanical injury to the vasculature. These types of blood flow are referred to as injurious pulsatile flow. In response to this mechanical injury, the vasculature develops plaques and other abnormalities in the vessel wall in a predictable pattern. A new tool, called a scanning-capillary-tube rheometer, to measure blood rheology has been developed. It can be used for the diagnosis and treatment of patients with a number of different diseases. Various clinical methods to improve blood properties will be presented.
6. 문 의 : 김민수 교수 (880-8362, minskim@snu.ac.kr)
2. 연 사 : Young I. Cho Professor
( Mechanical Engineering Department, Drexel University, Philadelphia, U.S.A.)
3. 일 시 : 2003년 9월 16일 (화) 16:00-17:00
4. 장 소 : 301동 1512호 (세미나실)
5. 내 용 :
Historically, atherosclerosis research has focused on the histology of the vascular wall and the biochemistry of clotting factors, platelets, prostaglandins and other biochemical factors. Although this “biochemical” approach to the study of atherogenesis has provided valuable information regarding the role played by histological and biochemical factors in the development of atherosclerosis, it has not identified the initiating event in atherosclerosis. The fundamental shortcoming of current biochemical theories is that they do not identify the initiating event that precedes endothelial injury.
We propose a protective adaptation theory, where a mechanical injury is the initiator of the endothelial injury. Damaged intima, lesions, and occlusions in the vascular system are secondary responses to mechanical injury that is directly related to the work of the heart. The arterial system is a dynamic system that naturally responds in various ways to different types of blood flow. In our approach, certain types of blood flow may cause mechanical injury to the vasculature. These types of blood flow are referred to as injurious pulsatile flow. In response to this mechanical injury, the vasculature develops plaques and other abnormalities in the vessel wall in a predictable pattern. A new tool, called a scanning-capillary-tube rheometer, to measure blood rheology has been developed. It can be used for the diagnosis and treatment of patients with a number of different diseases. Various clinical methods to improve blood properties will be presented.
6. 문 의 : 김민수 교수 (880-8362, minskim@snu.ac.kr)
